Connect Upstream for Robust Production

Mitigate raw material virus contamination risks with our new virus media filter. Eliminate cell growth concerns with Flexsafe® bags. Rely on proven stirred-tank design enhanced with single-use biomass measurement. Benefit from robust single-use clarification for up to 2000 L high performance fed-batch processes.

 

"This integrated upstream platform
mitigates contamination risks, reduces variability
and ensures successful single-use processing
up to 2000 liters."

Kevin Lynch,
Director Sales Integrated Solutions

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Virosart® Media

Virosart® Media is a virus retentive filter specially developed for upstream applications. The newly developed media filter overcomes today’s bottlenecks of virus filters originally developed for downstream applications and provides  a cost effective solution in upstream with highest filter capacity for cell culture media.

More about Virosart® Media

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BIOSTAT STR® 2000

The BIOSTAT STR® fully scalable, single-use bioreactor family offers working volumes from 50L to 2000L and is based on conventional stirred-tank design. It is now available in its second generation with improved hardware design, Flexsafe® STR bags for excellent cell growth, robustness and single-use, non-invasive biomass monitoring.

More about BIOSTAT STR® 2000

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Sartoclear Dynamics®

Sartoclear Dynamics® is a new single-use technology for harvesting animal cell cultures with high cell densities. Consistent results, ease of use, enormous speed and flexible scalability are the key characteristics of this technology. The ready-to-use clarification system enables single-use processing up to 2,000 liters. As a result, it replaces centrifuges and the subsequent depth filters in a single step.

More about Sartoclear Dynamics®

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Flexsafe® Bags

Flexsafe® bags ensure excellent and reproducible growth behavior, even with the most sensitive cell lines. Use our Flexsafe STR® bags for clinical or commercial production of your valuable product. Team up with our Flexsafe® RM bags in your seed train and our 3D bags for media storage. Benefit from the same polyethylene film material across all your cell culture steps.

More about Flexsafe® Bags

by Nick Hutchinson, Floris De Smet and Miriam Monge, September 2016

Developing an in-house bioprocessing competency prevents companies becoming dependent on external contractors. Single-use technology has greatly reduced the upfront costs required to install biomanufacturing capacity. In this article, the authors describe how a company can leverage external expertise in order to acquire the necessary skills to establish an internal production capability.

Download Medicine Maker article

by Anika Manzke and Birte Kleindienst, October 2016

The contamination of bioreactors with viruses is a potential risk to patient safety. In this article, authors from Sartorius Stedim Biotech describe how biomanufacturers can mitigate this risk with a new virus-retentive membrane for filtering chemical-defined cell culture media.

Download BioPharm International article

by Amélie Boulais, Nick Hutchinson and Fritjof Linz, September 2016

Single-use process platforms are helping biopharma companies reach the clinic more quickly and at lower cost.  In this tutorial we describe how manufacturers of Adenovirus vectors can use one such platform straight-from-the-box and with minimal optimization. Adopting a platform approach allows manufacturers to reduce time spent on process development and minimize engineering work when installing production capacity.

Download GEN tutorial

by Michael Sherman, Vincent Lam, Melissa Carpio, Nick Hutchinson and Christel Fenge, November 2016

In this article, the authors present data from a client showing the BIOSTAT® STR, single-use bioreactor to be highly effective for performing continuous cell cultures at the 2000-L scale. So efficient was the oxygen transfer within the BIOSTAT® STR it raises the possibility the client could perform a very demanding process in the single-use format that had, until this point, only been feasible within a stainless steel bioreactor.

Download article

by Nick Hutchinson, December 2016

Perfusion cell culture in single-use bioreactors is attracting considerable interest within the biopharmaceutical industry as an alternative to batch processes operated in large-scale stainless steel vessels. Dr Weichang Zhou (Senior Vice President, Biologics Development and Manufacturing) described WuXi Biologics’ approach to continuous bioprocess at Sartorius Stedim Biotech’s ‘China Bioprocess and Integrated Solution Innovation Forum’ held in September, 2016. Read an interview with Dr Zhou in which he discusses how intensified bioprocesses are increasing productivity in the biopharmaceutical industry.

Read interview in BioPharma Asia

Contact

Discuss your manufacturing plans with us. Let us know your questions and requests. You will hear from us shortly.

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Our Latest Upstream Innovations:

A Perfect Match for True Scalability in Single Use

The BIOSTAT STR® fully scalable, single-use bioreactor family offers working volumes from 12.5 L to 2000 L and is based on conventional stirred-tank design. It is now available in its 2nd generation with improved hardware design, Flexsafe STR® bags for excellent cell growth and robustness as well as with single-use, non-invasive biomass monitoring.

More about BIOSTAT STR® and Flexsafe STR®

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Robust Production – Reliable processing up to 2000 liters

BIOSTAT STR®

Let BIOSTAT STR® become your single-use bioreactor platform. Achieve excellent performance for high cell-density fed-batches due to excellent mixing, oxygen transfer and CO2 stripping. Successfully grow your shear sensitive cells on microcarriers in suspension culture thanks to the flexible stirrer and sparger options.

More about BIOSTAT STR®

Robust Production – Reliable processing up to 2000 liters

Flexsafe®

Flexsafe® bags ensure excellent and reproducible growth behavior, even with the most sensitive cell lines. Use our Flexsafe STR® bags for clinical or commercial production of your valuable product. Team up with our Flexsafe® RM bags in your seed train and our 3D bags for media storage. Benefit from the same polyethylene film material across all your cell culture steps.

More about Flexsafe®

Integrated Solutions - Discuss your manufacturing plans with us at any time

Our Integrated Solutions team designs, delivers and implements rapid and cost-effective biomanufacturing platforms – from process development to clinical to commercial manufacturing.

We combine our unmatched expertise in single-use bioprocess engineering with our fully integrated upstream platform and outstanding bioprocess technology portfolio for your process development, facility design and regulatory compliance. Discuss your manufacturing plans with us at any time.

More about Integrated Solutions

 
Our Integrated Solutions team designs, delivers and implements rapid and cost-effective biomanufacturing platforms
 

Cost Modelling of Bioprocesses by
Andrew Sinclair, Biopharm Services,
at the European Upstream & Downstream Forum 2016

Driving out costs from the manufacture of biologics is receiving greater attention within the biopharmaceutical industry. Modelling tools can help companies understand the impact of innovative bioprocessing technologies on process economics. Andrew Sinclair of Biopharm Services highlights how cost modelling successfully predicted that the adoption of single-use technologies by the industry would reduce biomanufacturing costs.

More about the Forum