Full At-line Integrated Analytics and Sample Collection

Combining the ambr® 15 and the BioProfile® FLEX2 enables fully integrated automatic sample transfer, analysis, and automated feedback control in each single-use ambr® 15 bioreactor. This allows collection of enormous quantities of cell culture data, including total and viable cell density, viability, cell diameter, pH, PCO2, PO2, glucose, lactate, glutamine, glutamate, ammonium, Na, K, Ca and osmolality, which can be sampled and measured with a complete cycle time of just 6-7 minutes.

Using this integrated system will allow scientists to run full quality by design (QbD) studies more easily, without causing a sampling bottleneck or needing additional staff resources. The new system will optimize your process productivity, as well as the quality of your biologics.

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Your Benefits:

  • Execute full QbD studies without creating sample bottlenecks
  • Rapid at-line sampling
  • Integrated data analytics
  • Get a full understanding of your critical cell culture parameters

More about these Upstream Innovation Products

ambr® 15 cell culture



Leading micro bioreactor system for cell line development and process optimization

ambr®15 is an automated microscale bioreactor system that replicates classical laboratory scale bioreactors. The benchtop system comprises disposable micro bioreactor vessels, an automated workstation and user friendly software. ambr® 15 offers automated parallel processing and control of 24 or 48 bioreactor experiments using just one operator. Designed to be installed in a standard laminar airflow biological safety cabinet for aseptic operation.  ambr® 15 provides efficient, consistent and scalable bioreactor experiments compared to classical laboratory bioreactors.

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BioProfile® FLEX2

Automated cell culture analyzer

BioProfile FLEX2 combines Nova’s groundbreaking MicroSensor Card technology with optical measurement and freezing point osmometry for an automated and comprehensive cell culture analyzer that eliminates chemistry sensor maintenance, increases analyzer speed, and reduces sample volume. Comprehensive test results including cell density/viability, pH/gases, and key chemistries are available in 4.5 minutes. Throughput for individual modules is 2.0 minutes.

Automated sampling from 96-well plates, syringes, or a 24-position external “load-and-go” sample tray provides maximum workflow flexibility and efficiency for cell culture

More about Nova BioProfile® FLEX2

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Contact us for more details on how at-line integrated analytics can accelerate your QbD studies.