Connect Upstream – The first fully integrated upstream platform

Integrated Upstream Platform -
From Cell Line to Manufacturing

Sartorius Stedim Biotech has developed the first fully integrated upstream platform. It connects a top-performing expression system with outstanding equipment and process control for the rapid development and scale-up of robust, high-titer commercial manufacturing processes.


Speed to Clinic

Reaching the clinical phase as quickly as possible is crucial. By combining the right tools and testing services, you'll develop your cell lines and processes in the fastest and most cost-effective way.

Reach the clinic faster




Increased Titers

Optimize your process for high titers to move on quickly to clinical trials. The unique CHOptimizer® solution helps you find the best media mixture, optimal process parameters and a successful feed strategy.

Increase your titers


Quality by Design

Optimal transitions between scales are essential from cell line to commercial manufacturing. With the right QbD strategy, you'll achieve robust, high-performing and retrievable processes.

Improve QbD


Robust Production

For long-term robust production, you'll need flexible and cost-effective biomanufacturing platforms. Our Integrated Solutions team will design, deliver and implement them for you – with unmatched expertise.

Build robust processes


Intensified Biomanufacturing

With the intensification of single-use upstream bioprocesses, your flexible multi-product facilities will have the highest production throughputs at lowest costs.

Intensify your process


Get More Control of Your Production Processes

With the release of SIMCA® 15 and SIMCA®-online 15 a number of new functionalities were added to the Umetrics™ Suite of Data Analytics. Find out how you can benefit from the seamless integration between the two solutions or how to use the web client to get a better overview of your production processes.

Join Us for the next ambr® Revolution

Our ambr® technology already increases your Speed to Clinic and makes upstream Quality by Design a reality. In early 2018, we will launch game-changing ambr® innovations for the bioprocess industry. Register here and be among the first to gain access to exclusive video content and first product reviews.

BPI Report: Advances in Single-Use Platforms for Commercial Manufacturing

New single-use systems allow biomanufacturers to adopt the technology in critical applications within their commercial-scale facilities. In this BioProcess International report, Sartorius Stedim Biotech explores recent advances in single-use process technologies and platforms for commercial production of biopharmaceuticals.

Research Xchange Forum: Early Bird Discount Ends on January 15

There are only a few days left to secure your early bird ticket for the upcoming Research Xchange Forum (March 20-21). So hurry up and register for our event in Goettingen, Germany, to gain insights into latest findings and best practices in regenerative medicine and cell therapy.

Case Study: Hoffman-Roche Uses DOE to Demonstrate Antibody Formula Robustness

This Quality by Design example case shows how a multivariate study can be used to successfully predict formulation robustness of a biopharmaceutical product with a specified shelf life. Download the free case study.

High Throughput Automated Microbial Bioreactor System Used for Clone Selection and Rapid Scale-Down Process Optimization

In this paper, the authors show that the ambr® 15f system is capable of supporting microbial fed-batch fermentations to high cell concentrations similar to benchtop and pilot scale fermenters. The results provide evidence that ambr® 15f is an efficient high throughput microbial system that can be used for strain and molecule selection as well as rapid scale-up.

How to Improve Your Production Processes

A real-time multivariate data analytics monitoring system such as SIMCA-online can help your production floor staff to know whether a process is performing optimally or not. Learn more about how using a multivariate data monitoring technology opens up a whole new world of possibilities for improving your production processes:


Your Guide to Upstream Processing Solutions

Upstream Catalog

Whether you just need a bioreactor or a single-use bag for media storage or are looking for a partner to build your completely single-use manufacturing facility, we will provide you with all the options, services and support you need.Our comprehensive upstream catalog consists of six chapters detailing our product portfolio throughout the upstream process. The catalog is dedicated to our cell line development services, media,  bioreactors and fermenters, clarification solutions, analytics and engineering services.Download the digitally optimized catalog as a PDF directly on your computer, tablet or smartphone.

Download upstream catalog

Addressing the Challenges of Developing Biopharmaceutical Drugs

by Stefan Schlack, 2016

The biopharmaceutical industry has enjoyed considerable success; however, there are strong signs this market is becoming increasingly competitive.

Stefan Schlack, Senior Vice President of Marketing & Product Management at Sartorius Stedim Biotech, shares his analysis of the industry as it stands in 2016 and offers solutions to the challenges the biopharmaceutical companies face.

Download article


Reduce your time to market and learn more about Sartorius Stedim Biotech’s unique integrated upstream platform. Let us know your questions and requests. You will hear from us shortly. For job enquiries, please visit our Careers page.



Total Solutions Support the Growth of a Dynamic Industry

Caine & Montgomery (2014) BPI 12(8) Sept. 23, 2014

In this interview with the team from BioProcess International, Reinhard Vogt (Executive Vice President of Marketing, Sales & Services, Executive Board member, Sartorius Stedim Biotech) and Stefan Schlack (Senior Vice President, Marketing & Product Management, Sartorius Stedim Biotech) discuss the need to move away from focusing on components and individual products and instead offer complete single-use solutions.

Reinhard Vogt: “Single-use technologies have reached a quality level similar to stainless steel”
Stefan Schlack: “Our industry faces four key challenges: capacity adaptation, smart process transfers, risk mitigation, and cost savings.”

The company’s recent acquisitions, together with its chemometrics offering, lay the foundation for QbD approaches as well as effective process optimization and characterization in a very short time frame and demonstrate the benefits of connecting upstream technologies.

Download BPI article


Events with Sartorius Stedim Biotech

Check here for events, conferences, trade fairs and more in your country. Just click on the icons of the continents for more information.

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Connect Upstream: The fully integrated process platform

December 1-2, 2016
Buenos Aires, Argentina

Connect Upstream: The fully integrated process platform

February 27 - March 2, 2017
BioProcess International West
San Francisco, CA, USA

February 27 - March 2, 2017
IFPAC Annual Meeting 2017
North Bethesda, MD, USA

March 7-8, 2017
2017 ISPE Aseptic Conference
Reston, VA, USA

March 14, 2017
Life Sciences Technology Conference
Raleigh, NC, USA

April 2-6, 2017
253rd ACS National Meeting & Exposition
San Francisco, CA, USA

April 3-5, 2017
2017 PDA Annual Meeting
Anaheim, CA, USA

May 1-5, 2017
PEGS – The Essential Protein & Antibody Engineering Summit
Boston, MA, USA

May 23-24, 2017
Cell Culture World Congress USA 2017
San Diego, CA, USA

May 23-24, 2017
World Biosimilar Congress USA 2017
San Diego, CA, USA

June 5-7, 2017
Cell Line Development & Engineering
San Diego, CA, USA

June 14-17, 2017
ISSCR 2017 Annual Meeting
Boston, MA, USA

August 13-17, 2017
Precision & Performance with Measurement Science
National Harbor, MD, USA

August 21-25, 2017
Bioprocessing Summit
Boston, MA, USA

September 20-22, 2017
World ADC San Diego
Sand Diego, CA, USA

September 25-28, 2017
BioProcess International Conference & Exhibition
Boston, MA, USA

October 4, 2017
ISPE Boston
Boston, MA, USA

October 29 - November 1, 2017
2017 ISPE Annual Meeting
San Diego, CA, USA

October 29 - November 1, 2017
RAFT – Recent Advances in Fermentation Technology
Bonita Springs (Ft. Myers), FL, USA

Connect Upstream: The fully integrated process platform

February 22-23, 2017
Research Xchange Forum
Goettingen, Germany

April 3-6, 2017
ISPE 2017 Europe Annual Conference
Barcelona, Spain

April 25-26, 2017
BioProcess International European Summit
Amsterdam, The Netherlands

April 25-27, 2017
Viral Safety & Raw Materials
Amsterdam, The Netherlands

May 14-17, 2017
25th ESACT Meeting
Lausanne, Switzerland

September 17-21, 2017
ECI: Integrated Continuous Biomanufacturing III
Cascais, Portugal

October 31 - November 2, 2017
European Antibody Congress 2017
Basel, Switzerland

November 7-8, 2017
Universe of Pre-filled Syringes & Injection Devices
Vienna, Austria

November 21-24, 2017
Moscow, Russia

Connect Upstream: The fully integrated process platform

March 12-14, 2017
14th China Association of Clinical Laboratory Practice (Intl.) Spring Expo
Qingdao, China

March 14, 2017
Sartorius Stedim Biopharma Forum 2017
Bangalore, India

March 17, 2017
Sartorius Stedim Biopharma Forum 2017
Mumbai, India

April 19-21, 2017
CIPM – China International Pharmaceutical Machinery Exposition
Qingdao, China

April 26-27, 2017
4th Pathogen Clean Asian Forum
Shanghai, China

June 20-22, 2017
CPHI China 2017
Shanghai, China