Connect Upstream – The first fully integrated upstream platform

Integrated Upstream Platform -
From Cell Line to Manufacturing

Sartorius Stedim Biotech has developed the first fully integrated upstream platform. It connects a top-performing expression system with outstanding equipment and process control for the rapid development and scale-up of robust, high-titer commercial manufacturing processes.

 
 

Speed to Clinic

Reaching the clinical phase as quickly as possible is crucial. By combining the right tools and testing services, you'll develop your cell lines and processes in the fastest and most cost-effective way.

Reach the clinic faster

 

 

 

Increased Titers

Optimize your process for high titers to move on quickly to clinical trials. The unique CHOptimizer® solution helps you find the best media mixture, optimal process parameters and a successful feed strategy.

Increase your titers

 

Quality by Design

Optimal transitions between scales are essential from cell line to commercial manufacturing. With the right QbD strategy, you'll achieve robust, high-performing and retrievable processes.

Improve QbD

 

Robust Production

For long-term robust production, you'll need flexible and cost-effective biomanufacturing platforms. Our Integrated Solutions team will design, deliver and implement them for you – with unmatched expertise.

Build robust processes

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"Our upstream platform
connects outstanding process
technologies and brings biology
to single-use bioprocessing."

 

 

Stefan Schlack,
Senior Vice President, Marketing & Product Management Bioprocess Solutions

News

BIOSTAT® A – Your Professional Start in Cell Cultivation and Microbial Fermentation
(2017-12-12)

Thanks to the intuitive user interface, operating the BIOSTAT® A is ideal for beginners, reduces operating errors and speeds up training. Learn more about how the fast load peristaltic pumps, convenient data analysis and other features of this entry-level bioreactor | fermenter make your life easier.

Try Our New BioPAT® MFCS 4.3 for Free
(2017-12-08)

BioPAT® MFCS 4.3 allows you to realize advanced process strategies and benefit from PAT by integration of additional analytical devices. Its efficient data acquisition and trend monitoring make it an ideal tool for both R&D and process development. Test BioPAT® MFCS 4.3 now for free. A 90-day demo version of the new release is available for download on our website.

A Perfect Match for True Scalability in Single-Use
(2017-12-07)

Our BIOSTAT STR® bioreactors are now available with improved hardware design, Flexsafe STR® bags for excellent cell growth and robustness as well as with single-use, non-invasive biomass monitoring. The fully scalable bioreactor family offers working volumes from 50 L to 2000 L and is based on conventional stirred-tank design.

Webinar: Integration Strategies for Commercial Single-Use Biomanufacturing Facilities
(2017-12-06)

Developing a single-use technology integration concept requires a deep understanding of possible technical solutions. This recorded webinar describes the necessary considerations for developing a fully integrated single-use process using examples from the industry.

Attend Our Upstream Trainings at CBT, IIT Delhi
(2017-12-06)

Sartorius Stedim Biotech is participating in the upcoming CBT course series at IIT Delhi, on December 6-8. Register now for our training sessions on Quality by Design, Multivariate Data Analysis and Design of Experiments. Learn more:

Improved Clone Evaluation and Selection of CHO Cell Lines Using ambr® 15
(2017-12-04)

As part of the continuous improvement of our cell line development platform we implemented ambr® 15 to perform the clone evaluation and selection of CHO cell lines. In this study, clone evaluation using the ambr® 15 system was compared to clone assessment in benchtop bioreactor systems and conventional shake flasks for a CHO production system.

Total Characterization Testing Services for Biologics
(2017-12-01)

The BioOutsource analytical testing package combines physicochemical and biological analysis for in-depth characterization and comparability studies from one contract partner. Available from pre-clinical through clinical phases and lot release.

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Your Guide to Upstream Processing Solutions

Upstream Catalog

Whether you just need a bioreactor or a single-use bag for media storage or are looking for a partner to build your completely single-use manufacturing facility, we will provide you with all the options, services and support you need.Our comprehensive upstream catalog consists of six chapters detailing our product portfolio throughout the upstream process. The catalog is dedicated to our cell line development services, media,  bioreactors and fermenters, clarification solutions, analytics and engineering services.Download the digitally optimized catalog as a PDF directly on your computer, tablet or smartphone.

Download upstream catalog

Addressing the Challenges of Developing Biopharmaceutical Drugs

by Stefan Schlack, 2016

The biopharmaceutical industry has enjoyed considerable success; however, there are strong signs this market is becoming increasingly competitive.

Stefan Schlack, Senior Vice President of Marketing & Product Management at Sartorius Stedim Biotech, shares his analysis of the industry as it stands in 2016 and offers solutions to the challenges the biopharmaceutical companies face.

Download article

Contact

Reduce your time to market and learn more about Sartorius Stedim Biotech’s unique integrated upstream platform. Let us know your questions and requests. You will hear from us shortly. For job enquiries, please visit our Careers page.

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Total Solutions Support the Growth of a Dynamic Industry

Caine & Montgomery (2014) BPI 12(8) Sept. 23, 2014

In this interview with the team from BioProcess International, Reinhard Vogt (Executive Vice President of Marketing, Sales & Services, Executive Board member, Sartorius Stedim Biotech) and Stefan Schlack (Senior Vice President, Marketing & Product Management, Sartorius Stedim Biotech) discuss the need to move away from focusing on components and individual products and instead offer complete single-use solutions.

Reinhard Vogt: “Single-use technologies have reached a quality level similar to stainless steel”
Stefan Schlack: “Our industry faces four key challenges: capacity adaptation, smart process transfers, risk mitigation, and cost savings.”

The company’s recent acquisitions, together with its chemometrics offering, lay the foundation for QbD approaches as well as effective process optimization and characterization in a very short time frame and demonstrate the benefits of connecting upstream technologies.

Download BPI article

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Events with Sartorius Stedim Biotech

Check here for events, conferences, trade fairs and more in your country. Just click on the icons of the continents for more information.

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Connect Upstream: The fully integrated process platform

December 1-2, 2016
ETIF
Buenos Aires, Argentina

Connect Upstream: The fully integrated process platform

February 27 - March 2, 2017
BioProcess International West
San Francisco, CA, USA

February 27 - March 2, 2017
IFPAC Annual Meeting 2017
North Bethesda, MD, USA

March 7-8, 2017
2017 ISPE Aseptic Conference
Reston, VA, USA

March 14, 2017
Life Sciences Technology Conference
Raleigh, NC, USA

April 2-6, 2017
253rd ACS National Meeting & Exposition
San Francisco, CA, USA

April 3-5, 2017
2017 PDA Annual Meeting
Anaheim, CA, USA

May 1-5, 2017
PEGS – The Essential Protein & Antibody Engineering Summit
Boston, MA, USA

May 23-24, 2017
Cell Culture World Congress USA 2017
San Diego, CA, USA

May 23-24, 2017
World Biosimilar Congress USA 2017
San Diego, CA, USA

June 5-7, 2017
Cell Line Development & Engineering
San Diego, CA, USA

June 14-17, 2017
ISSCR 2017 Annual Meeting
Boston, MA, USA

August 13-17, 2017
Precision & Performance with Measurement Science
National Harbor, MD, USA

August 21-25, 2017
Bioprocessing Summit
Boston, MA, USA

September 20-22, 2017
World ADC San Diego
Sand Diego, CA, USA

September 25-28, 2017
BioProcess International Conference & Exhibition
Boston, MA, USA

October 4, 2017
ISPE Boston
Boston, MA, USA

October 29 - November 1, 2017
2017 ISPE Annual Meeting
San Diego, CA, USA

October 29 - November 1, 2017
RAFT – Recent Advances in Fermentation Technology
Bonita Springs (Ft. Myers), FL, USA

Connect Upstream: The fully integrated process platform

February 22-23, 2017
Research Xchange Forum
Goettingen, Germany

April 3-6, 2017
ISPE 2017 Europe Annual Conference
Barcelona, Spain

April 25-26, 2017
BioProcess International European Summit
Amsterdam, The Netherlands

April 25-27, 2017
Viral Safety & Raw Materials
Amsterdam, The Netherlands

May 14-17, 2017
25th ESACT Meeting
Lausanne, Switzerland

September 17-21, 2017
ECI: Integrated Continuous Biomanufacturing III
Cascais, Portugal

October 31 - November 2, 2017
European Antibody Congress 2017
Basel, Switzerland

November 7-8, 2017
Universe of Pre-filled Syringes & Injection Devices
Vienna, Austria

November 21-24, 2017
Pharmtech
Moscow, Russia

Connect Upstream: The fully integrated process platform

March 12-14, 2017
14th China Association of Clinical Laboratory Practice (Intl.) Spring Expo
Qingdao, China

March 14, 2017
Sartorius Stedim Biopharma Forum 2017
Bangalore, India

March 17, 2017
Sartorius Stedim Biopharma Forum 2017
Mumbai, India

April 19-21, 2017
CIPM – China International Pharmaceutical Machinery Exposition
Qingdao, China

April 26-27, 2017
4th Pathogen Clean Asian Forum
Shanghai, China

June 20-22, 2017
CPHI China 2017
Shanghai, China

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